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Replimune Group, Inc. (REPL) Fundamental Analysis & AI Grade 2026

REPL Nasdaq Biological Products, (No Diagnostic Substances) DE CIK: 0001737953
Updated This Month • Analysis: Jul 29, 2026 • SEC Data: 2026-03-31
Combined AI Grade
C
88% Confidence
AGREEMENT
C
82% Conf
D
94% Conf

📊 REPL Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-284.6M
Current Ratio: 4.79x
Debt/Equity: 0.50x
EPS: $-3.38
AI Grade: C with 82% confidence
Replimune Group, Inc. (REPL) receives a C fundamental grade with 88% confidence from our AI analysis based on SEC 10-K filings. With revenue of $0, and return on equity (ROE) of -188.9%, Replimune Group, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete REPL stock analysis for 2026.

Is Replimune Group, Inc. (REPL) a Good Investment?

Claude

Replimune is a pre-revenue clinical-stage biotech with -$319.9M operating loss and -$280.3M annual cash burn, leaving only ~9 months of runway despite a $209M cash position. The company has zero commercial revenue and is entirely dependent on uncertain clinical trial outcomes, with no clear path to profitability in the near term based on current financial fundamentals.

ChatGPT

Replimune remains pre-revenue while operating losses, negative returns, and cash consumption are exceptionally high, with diluted EPS deteriorating year over year. Although near-term liquidity is strong, the current free-cash-flow burn exceeds cash reserves on an annualized basis, creating substantial financing and dilution risk without demonstrated commercial growth.

Replimune Group, Inc. Key Strengths (REPL)

Claude
  • + Strong cash position of $209.0M provides operational runway for planned studies
  • + Excellent liquidity with 4.79x current ratio indicating ability to meet short-term obligations
  • + Conservative leverage at 0.50x debt-to-equity ratio with manageable debt service
ChatGPT
  • + Strong current and quick ratios of 4.79x
  • + Cash and equivalents of $209.02M provide a meaningful liquidity buffer
  • + Moderate long-term debt relative to equity at 0.50x

REPL Stock Risks: Replimune Group, Inc. Investment Risks

Claude
  • ! Zero revenue with no commercial-stage products generating sales
  • ! Unsustainable burn rate of $280.3M annually leaves only ~9 months of cash runway
  • ! Complete financial dependence on uncertain clinical trial outcomes and FDA approval - binary risk
  • ! High likelihood of dilutive capital raise required before reaching profitability or positive cash flow
  • ! Negative ROE (-188.9%) and ROA (-94.4%) reflect severe operational losses
ChatGPT
  • ! No revenue or gross profit to support operating expenses
  • ! Free cash flow of negative $284.57M indicates an unsustainable cash-burn rate
  • ! Deeply negative ROE and ROA signal rapid destruction of shareholder capital

Key Metrics to Watch

Claude
  • * Cash runway and burn rate trajectory - critical for assessing capital raise timing
  • * Clinical trial progress and milestone achievements
  • * Quarterly cash burn trend - any improvement would extend runway
ChatGPT
  • * Quarterly operating cash burn and remaining cash runway
  • * Revenue generation and operating-expense trajectory

Replimune Group, Inc. (REPL) Financial Metrics & Key Ratios

Revenue
$0.0
Net Income
$-313.9M
EPS (Diluted)
$-3.38
Free Cash Flow
$-284.6M
Total Assets
$332.4M
Cash Position
$209.0M

💡 AI Analyst Insight

Strong liquidity with a 4.79x current ratio provides a solid financial cushion.

REPL Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -188.9%
ROA -94.4%
FCF Margin N/A

REPL vs Healthcare Sector: How Replimune Group, Inc. Compares

How Replimune Group, Inc. compares to Healthcare sector averages

Net Margin
REPL 0.0%
vs
Sector Avg 12.0%
REPL Sector
ROE
REPL -188.9%
vs
Sector Avg 15.0%
REPL Sector
Current Ratio
REPL 4.8x
vs
Sector Avg 2.0x
REPL Sector
Debt/Equity
REPL 0.5x
vs
Sector Avg 0.6x
REPL Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Replimune Group, Inc. Stock Overvalued? REPL Valuation Analysis 2026

Based on fundamental analysis, Replimune Group, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-188.9%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.50x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Replimune Group, Inc. Balance Sheet: REPL Debt, Cash & Liquidity

Current Ratio
4.79x
Quick Ratio
4.79x
Debt/Equity
0.50x
Debt/Assets
50.0%
Interest Coverage
-47.07x
Long-term Debt
$83.3M

REPL Revenue & Earnings Growth: 5-Year Financial Trend

REPL 5-year financial data:
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Replimune Group, Inc.'s revenue has remained relatively flat over the 5-year period, with a 0% decline. The most recent EPS of $-3.07 indicates the company is currently unprofitable.

REPL Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

REPL Quarterly Earnings & Performance

Quarterly financial performance data for Replimune Group, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2018 N/A -$4.2M N/A
Q2 2018 N/A -$4.0M N/A
Q1 2018 N/A -$2.6M N/A

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Replimune Group, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$280.3M
Cash generated from operations
Capital Expenditures
$4.2M
Investment in assets
Dividends
None
No dividend program

REPL SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Replimune Group, Inc. (CIK: 0001737953)

📋 Recent SEC Filings

Date Form Document Action
Aug 12, 2026 4 xslF345X06/tm2623037-4_4seq1.xml View →
Aug 12, 2026 4 xslF345X06/tm2623037-3_4seq1.xml View →
Aug 12, 2026 4 xslF345X06/tm2623037-2_4seq1.xml View →
Aug 12, 2026 4 xslF345X06/tm2623037-1_4seq1.xml View →
Aug 11, 2026 4 xslF345X06/ownership.xml View →

Frequently Asked Questions about REPL

What is the AI rating for REPL?

Replimune Group, Inc. (REPL) has a Combined AI Grade of C from Claude (C) and ChatGPT (D) with 88% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are REPL's key strengths?

Claude: Strong cash position of $209.0M provides operational runway for planned studies. Excellent liquidity with 4.79x current ratio indicating ability to meet short-term obligations. ChatGPT: Strong current and quick ratios of 4.79x. Cash and equivalents of $209.02M provide a meaningful liquidity buffer.

What are the risks of investing in REPL?

Claude: Zero revenue with no commercial-stage products generating sales. Unsustainable burn rate of $280.3M annually leaves only ~9 months of cash runway. ChatGPT: No revenue or gross profit to support operating expenses. Free cash flow of negative $284.57M indicates an unsustainable cash-burn rate.

What is REPL's revenue and growth?

Replimune Group, Inc. reported revenue of $0.0.

Does REPL pay dividends?

Replimune Group, Inc. does not currently pay dividends.

Where can I find REPL SEC filings?

Official SEC filings for Replimune Group, Inc. (CIK: 0001737953) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is REPL's EPS?

Replimune Group, Inc. has a diluted EPS of $-3.38.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is REPL's fundamental grade?

Based on our AI fundamental analysis in August 2026, Replimune Group, Inc. has a C grade with 88% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is REPL stock overvalued or undervalued?

Valuation metrics for REPL: ROE of -188.9% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is REPL's AI grade for 2026?

Our dual AI analysis gives Replimune Group, Inc. a combined C grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is REPL's free cash flow?

Replimune Group, Inc.'s operating cash flow is $-280.3M, with capital expenditures of $4.2M.

How does REPL compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -188.9% (avg: 15%), current ratio 4.79 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Jul 29, 2026 | Data as of: 2026-03-31 | Powered by Claude AI