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Aptevo Therapeutics Inc. (APVO) Fundamental Analysis & AI Grade 2026

APVO Nasdaq Pharmaceutical Preparations DE CIK: 0001671584
Updated This Month • Analysis: May 23, 2026 • SEC Data: 2026-03-31
Combined AI Grade
D
90% Confidence
STRONG AGREEMENT
D
87% Conf
D
94% Conf

📊 APVO Key Takeaways

Revenue: $3.1M
Net Margin: -215.1%
Free Cash Flow: $-8.0M
Current Ratio: 3.36x
Debt/Equity: 0.00x
EPS: $-6.41
AI Grade: D with 87% confidence
Aptevo Therapeutics Inc. (APVO) receives a D fundamental grade with 90% confidence from our AI analysis based on SEC 10-K filings. With revenue of $3.1M, net profit margin of -215.1%, and return on equity (ROE) of -57.7%, Aptevo Therapeutics Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete APVO stock analysis for 2026.

Is Aptevo Therapeutics Inc. (APVO) a Good Investment?

Claude

Aptevo is a pharmaceutical company experiencing catastrophic revenue decline of 74.7% YoY while burning $8M annually from operations against only $3.1M in revenue, indicating a fundamentally broken business model. Despite maintaining adequate cash reserves of $14.5M and zero debt, the company's unsustainable cash burn rate combined with negative margins exceeding -215% suggests insolvency within approximately 18-24 months without material business recovery.

ChatGPT

Aptevo Therapeutics shows very weak fundamentals, with revenue down 74.7% year over year and extremely negative operating and net margins, indicating the business is not currently converting its pipeline or collaborations into sustainable income. While the balance sheet has low leverage and meaningful cash relative to liabilities, the company is burning over $20M in annual operating cash flow against only $21.06M of cash, creating significant funding and dilution risk unless operating performance improves materially.

Aptevo Therapeutics Inc. Key Strengths (APVO)

Claude
  • + Strong cash position of $14.5M provides runway for near-term operations
  • + No long-term debt; leverage is not a compounding risk factor
  • + Adequate short-term liquidity ratios (current ratio 3.36x) for immediate obligations
ChatGPT
  • + Strong liquidity profile with a 4.03x current ratio and no long-term debt
  • + Cash balance of $21.06M exceeds total liabilities of $9.60M, providing short-term financial flexibility
  • + Positive equity base of $17.39M supports balance sheet stability relative to many distressed biotech peers

APVO Stock Risks: Aptevo Therapeutics Inc. Investment Risks

Claude
  • ! Catastrophic 74.7% revenue decline YoY indicates fundamental loss of market or product viability
  • ! Unsustainable operating cash burn of $8M annually against $3.1M revenue creates solvency risk within ~2 years
  • ! Deeply negative margins (-219.6% operating, -215.1% net) with no visible path to profitability
  • ! Zero insider Form 4 activity suggests lack of confidence or trading restrictions from management
ChatGPT
  • ! Revenue collapsed 74.7% year over year, signaling poor growth quality and unstable commercialization or collaboration income
  • ! Operating loss of $20.32M and free cash flow of -$20.39M indicate an unsustainable cash burn rate
  • ! Severely negative profitability metrics, including -652.4% operating margin and -115.9% ROE, reflect weak business economics

Key Metrics to Watch

Claude
  • * Quarterly revenue trend and stabilization of decline
  • * Operating cash burn rate and runway months of cash remaining
  • * Clinical/regulatory progress if pipeline advancement can validate future revenue potential
ChatGPT
  • * Quarterly cash burn versus cash and equivalents
  • * Revenue trajectory and any improvement in operating loss

Aptevo Therapeutics Inc. (APVO) Financial Metrics & Key Ratios

Revenue
$3.1M
Net Income
$-6.7M
EPS (Diluted)
$-6.41
Free Cash Flow
$-8.0M
Total Assets
$19.9M
Cash Position
$14.5M

💡 AI Analyst Insight

Strong liquidity with a 3.36x current ratio provides a solid financial cushion.

APVO Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -219.6%
Net Margin -215.1%
ROE -57.7%
ROA -33.6%
FCF Margin -256.7%

APVO vs Healthcare Sector: How Aptevo Therapeutics Inc. Compares

How Aptevo Therapeutics Inc. compares to Healthcare sector averages

Net Margin
APVO -215.1%
vs
Sector Avg 12.0%
APVO Sector
ROE
APVO -57.7%
vs
Sector Avg 15.0%
APVO Sector
Current Ratio
APVO 3.4x
vs
Sector Avg 2.0x
APVO Sector
Debt/Equity
APVO 0.0x
vs
Sector Avg 0.6x
APVO Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Aptevo Therapeutics Inc. Stock Overvalued? APVO Valuation Analysis 2026

Based on fundamental analysis, Aptevo Therapeutics Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-57.7%
Sector avg: 15%
Net Profit Margin
-215.1%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Aptevo Therapeutics Inc. Balance Sheet: APVO Debt, Cash & Liquidity

Current Ratio
3.36x
Quick Ratio
2.07x
Debt/Equity
0.00x
Debt/Assets
41.7%
Interest Coverage
N/A
Long-term Debt
$0.0

APVO Revenue & Earnings Growth: 5-Year Financial Trend

APVO 5-year financial data: Year 2019: Revenue $32.4M, Net Income N/A, EPS N/A. Year 2020: Revenue $4.3M, Net Income N/A, EPS N/A. Year 2021: Revenue $12.3M, Net Income -$17.8M, EPS N/A. Year 2022: Revenue $12.3M, Net Income -$28.5M, EPS $-6.07. Year 2023: Revenue $3.1M, Net Income $8.0M, EPS $1.57.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Aptevo Therapeutics Inc.'s revenue has declined by 90% over the 5-year period, indicating business contraction. The most recent EPS of $-31,460.23 indicates the company is currently unprofitable.

APVO Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-256.7%
Free cash flow / Revenue

APVO Quarterly Earnings & Performance

Quarterly financial performance data for Aptevo Therapeutics Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2023 $3.1M $2.8M $-0.50
Q2 2023 $3.1M $2.8M $-0.72
Q1 2023 $3.1M $2.8M $0.26
Q3 2022 $3.1M -$7.0M $-1.43
Q2 2022 $3.1M -$7.3M $-1.75
Q1 2022 $2.4M -$7.3M N/A
Q3 2021 $1.5M $2.9M N/A
Q2 2021 $473.0K $2.9M N/A

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Aptevo Therapeutics Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$8.0M
Cash generated from operations
Capital Expenditures
$29.0K
Investment in assets
Dividends
None
No dividend program

APVO SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Aptevo Therapeutics Inc. (CIK: 0001671584)

📋 Recent SEC Filings

Date Form Document Action
May 27, 2026 8-K apvo-20260525.htm View →
May 13, 2026 10-Q apvo-20260331.htm View →
May 13, 2026 8-K apvo-20260513.htm View →
May 6, 2026 8-K apvo-20260506.htm View →
Mar 26, 2026 10-K apvo-20251231.htm View →

Frequently Asked Questions about APVO

What is the AI rating for APVO?

Aptevo Therapeutics Inc. (APVO) has a Combined AI Grade of D from Claude (D) and ChatGPT (D) with 90% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are APVO's key strengths?

Claude: Strong cash position of $14.5M provides runway for near-term operations. No long-term debt; leverage is not a compounding risk factor. ChatGPT: Strong liquidity profile with a 4.03x current ratio and no long-term debt. Cash balance of $21.06M exceeds total liabilities of $9.60M, providing short-term financial flexibility.

What are the risks of investing in APVO?

Claude: Catastrophic 74.7% revenue decline YoY indicates fundamental loss of market or product viability. Unsustainable operating cash burn of $8M annually against $3.1M revenue creates solvency risk within ~2 years. ChatGPT: Revenue collapsed 74.7% year over year, signaling poor growth quality and unstable commercialization or collaboration income. Operating loss of $20.32M and free cash flow of -$20.39M indicate an unsustainable cash burn rate.

What is APVO's revenue and growth?

Aptevo Therapeutics Inc. reported revenue of $3.1M.

Does APVO pay dividends?

Aptevo Therapeutics Inc. does not currently pay dividends.

Where can I find APVO SEC filings?

Official SEC filings for Aptevo Therapeutics Inc. (CIK: 0001671584) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is APVO's EPS?

Aptevo Therapeutics Inc. has a diluted EPS of $-6.41.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is APVO's fundamental grade?

Based on our AI fundamental analysis in June 2026, Aptevo Therapeutics Inc. has a D grade with 90% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is APVO stock overvalued or undervalued?

Valuation metrics for APVO: ROE of -57.7% (sector avg: 15%), net margin of -215.1% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is APVO's AI grade for 2026?

Our dual AI analysis gives Aptevo Therapeutics Inc. a combined D grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is APVO's free cash flow?

Aptevo Therapeutics Inc.'s operating cash flow is $-8.0M, with capital expenditures of $29.0K. FCF margin is -256.7%.

How does APVO compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -215.1% (avg: 12%), ROE -57.7% (avg: 15%), current ratio 3.36 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 23, 2026 | Data as of: 2026-03-31 | Powered by Claude AI