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Prelude Therapeutics Inc (PRLD) Fundamental Analysis & AI Grade 2026

PRLD Nasdaq Pharmaceutical Preparations DE CIK: 0001678660
Updated This Month • Analysis: May 13, 2026 • SEC Data: 2026-03-31
Combined AI Grade
D
75% Confidence
N/A
D
75% Conf
Pending
Analysis scheduled

📊 PRLD Key Takeaways

Revenue: $4.6M
Net Margin: -226.7%
Free Cash Flow: $-21.7M
Current Ratio: 2.03x
Debt/Equity: 0.00x
EPS: $-0.13
AI Grade: D with 75% confidence
Prelude Therapeutics Inc (PRLD) receives a D fundamental grade with 75% confidence from our AI analysis based on SEC 10-K filings. With revenue of $4.6M, net profit margin of -226.7%, and return on equity (ROE) of -17.3%, Prelude Therapeutics Inc demonstrates mixed fundamentals in the Healthcare sector. Below is our complete PRLD stock analysis for 2026.

Is Prelude Therapeutics Inc (PRLD) a Good Investment?

Claude

Prelude Therapeutics exhibits unsustainable financial fundamentals with critical cash runway of <12 months at current burn rates. With operating cash flow of -21.7M against only 21.8M cash reserves and revenue of 4.6M, the company faces urgent near-term financing needs that create significant downside risk.

Prelude Therapeutics Inc Key Strengths (PRLD)

Claude
  • + Revenue growth of 73.4% YoY demonstrates emerging commercial traction despite small base
  • + Zero debt with positive stockholders equity of 60.2M provides clean balance sheet
  • + Current and quick ratios of 2.03x indicate adequate near-term liquidity for operations

PRLD Stock Risks: Prelude Therapeutics Inc Investment Risks

Claude
  • ! Cash runway of approximately 12 months at current 21.7M annual operating burn rate requires imminent financing
  • ! Operating loss of 14.2M on 4.6M revenue demonstrates severe unit economics and unprofitability
  • ! Operating margin of -309% and net margin of -227% indicate business model is fundamentally challenged

Key Metrics to Watch

Claude
  • * Path to operating cash flow breakeven and burn rate reduction trajectory
  • * Revenue growth sustainability and achievement of positive gross margins on commercial products
  • * Cash position, financing announcements, and dilution from equity raises

Prelude Therapeutics Inc (PRLD) Financial Metrics & Key Ratios

Revenue
$4.6M
Net Income
$-10.4M
EPS (Diluted)
$-0.13
Free Cash Flow
$-21.7M
Total Assets
$119.6M
Cash Position
$21.8M

💡 AI Analyst Insight

Strong liquidity with a 2.03x current ratio provides a solid financial cushion.

PRLD Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -309.5%
Net Margin -226.7%
ROE -17.3%
ROA -8.7%
FCF Margin -473.5%

PRLD vs Healthcare Sector: How Prelude Therapeutics Inc Compares

How Prelude Therapeutics Inc compares to Healthcare sector averages

Net Margin
PRLD -226.7%
vs
Sector Avg 12.0%
PRLD Sector
ROE
PRLD -17.3%
vs
Sector Avg 15.0%
PRLD Sector
Current Ratio
PRLD 2.0x
vs
Sector Avg 2.0x
PRLD Sector
Debt/Equity
PRLD 0.0x
vs
Sector Avg 0.6x
PRLD Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Prelude Therapeutics Inc Stock Overvalued? PRLD Valuation Analysis 2026

Based on fundamental analysis, Prelude Therapeutics Inc has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-17.3%
Sector avg: 15%
Net Profit Margin
-226.7%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Prelude Therapeutics Inc Balance Sheet: PRLD Debt, Cash & Liquidity

Current Ratio
2.03x
Quick Ratio
2.03x
Debt/Equity
0.00x
Debt/Assets
49.7%
Interest Coverage
N/A
Long-term Debt
N/A

PRLD Revenue & Earnings Growth: 5-Year Financial Trend

PRLD 5-year financial data: Year 2024: Revenue $7.0M, Net Income -$121.8M, EPS $-2.02. Year 2025: Revenue $12.1M, Net Income -$127.2M, EPS $-1.68.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Prelude Therapeutics Inc's revenue has grown significantly by 73% over the 5-year period, indicating strong business expansion. The most recent EPS of $-1.68 indicates the company is currently unprofitable.

PRLD Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-473.5%
Free cash flow / Revenue

PRLD Quarterly Earnings & Performance

Quarterly financial performance data for Prelude Therapeutics Inc including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 N/A -$10.4M $-0.13
Q3 2025 $3.0M -$19.7M $-0.26
Q3 2024 $3.0M -$27.7M $-0.43

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Prelude Therapeutics Inc Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$21.7M
Cash generated from operations
Dividends
None
No dividend program

PRLD SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Prelude Therapeutics Inc (CIK: 0001678660)

📋 Recent SEC Filings

Date Form Document Action
May 12, 2026 10-Q prld-20260331.htm View →
May 12, 2026 8-K prld-20260512.htm View →
May 4, 2026 4 xslF345X06/primarydocument.xml View →
Apr 29, 2026 DEF 14A prld-20260429.htm View →
Apr 28, 2026 4 xslF345X06/form4-04282026_090449.xml View →

Frequently Asked Questions about PRLD

What is the AI rating for PRLD?

Prelude Therapeutics Inc (PRLD) has an AI grade of D with 75% confidence, based on fundamental analysis of SEC EDGAR filings.

What are PRLD's key strengths?

Claude: Revenue growth of 73.4% YoY demonstrates emerging commercial traction despite small base. Zero debt with positive stockholders equity of 60.2M provides clean balance sheet.

What are the risks of investing in PRLD?

Claude: Cash runway of approximately 12 months at current 21.7M annual operating burn rate requires imminent financing. Operating loss of 14.2M on 4.6M revenue demonstrates severe unit economics and unprofitability.

What is PRLD's revenue and growth?

Prelude Therapeutics Inc reported revenue of $4.6M.

Does PRLD pay dividends?

Prelude Therapeutics Inc does not currently pay dividends.

Where can I find PRLD SEC filings?

Official SEC filings for Prelude Therapeutics Inc (CIK: 0001678660) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is PRLD's EPS?

Prelude Therapeutics Inc has a diluted EPS of $-0.13.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is PRLD's fundamental grade?

Based on our AI fundamental analysis in June 2026, Prelude Therapeutics Inc has a D grade with 75% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is PRLD stock overvalued or undervalued?

Valuation metrics for PRLD: ROE of -17.3% (sector avg: 15%), net margin of -226.7% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is PRLD's AI grade for 2026?

Our dual AI analysis gives Prelude Therapeutics Inc a combined D grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is PRLD's free cash flow?

Prelude Therapeutics Inc's operating cash flow is $-21.7M, with capital expenditures of $0.0. FCF margin is -473.5%.

How does PRLD compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -226.7% (avg: 12%), ROE -17.3% (avg: 15%), current ratio 2.03 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 13, 2026 | Data as of: 2026-03-31 | Powered by Claude AI