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Taysha Gene Therapies, Inc. (TSHA) Fundamental Analysis & AI Grade 2026

TSHA Nasdaq Biological Products, (No Diagnostic Substances) DE CIK: 0001806310
Update Pending • Analysis: May 8, 2026 • SEC Data: 2026-03-31
Combined AI Grade
B
65% Confidence
N/A
B
65% Conf
Pending
Analysis scheduled

📊 TSHA Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-40.9M
Current Ratio: 14.04x
Debt/Equity: 0.23x
EPS: $-0.12
AI Grade: B with 65% confidence
Taysha Gene Therapies, Inc. (TSHA) receives a B fundamental grade with 65% confidence from our AI analysis based on SEC 10-K filings. With revenue of $0, and return on equity (ROE) of -20.0%, Taysha Gene Therapies, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete TSHA stock analysis for 2026.

Is Taysha Gene Therapies, Inc. (TSHA) a Good Investment?

Claude

Taysha Gene Therapies maintains exceptional financial health with $276.6M in cash and 14x liquidity providing 6-7+ years of operational runway, significantly reducing near-term solvency risk. However, the company remains pre-revenue with consistent $40M+ annual operating losses, and investment merit depends entirely on clinical program success with no proven pathway to profitability visible in current fundamentals.

Taysha Gene Therapies, Inc. Key Strengths (TSHA)

Claude
  • + Exceptional cash position of $276.6M with minimal capex needs, providing substantial operational runway
  • + Strong balance sheet with 14.04x current ratio and conservative 0.23x debt-to-equity leverage
  • + Slight improvement in EPS loss trajectory (+5.6% YoY) indicating potential operational efficiency gains

TSHA Stock Risks: Taysha Gene Therapies, Inc. Investment Risks

Claude
  • ! Zero revenue generation with no clear commercialization timeline or product approval visibility
  • ! Annual operating burn of $40.9M requires successful R&D execution to justify cash deployment
  • ! Clinical-stage biotech with high technical and regulatory risk; failed programs could rapidly deplete capital reserves
  • ! Future financing likely required; equity dilution risk if clinical failures accelerate cash burn

Key Metrics to Watch

Claude
  • * Quarterly cash burn rate trend (acceleration vs. deceleration indicates program traction)
  • * Clinical trial progression and regulatory milestones for pipeline programs
  • * Months of cash runway remaining relative to program development timeline
  • * Any revenue generation from partnerships, licensing, or product approvals

Taysha Gene Therapies, Inc. (TSHA) Financial Metrics & Key Ratios

Revenue
$0.0
Net Income
$-42.4M
EPS (Diluted)
$-0.12
Free Cash Flow
$-40.9M
Total Assets
$300.4M
Cash Position
$276.6M

💡 AI Analyst Insight

Strong liquidity with a 14.04x current ratio provides a solid financial cushion.

TSHA Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -20.0%
ROA -14.1%
FCF Margin N/A

TSHA vs Healthcare Sector: How Taysha Gene Therapies, Inc. Compares

How Taysha Gene Therapies, Inc. compares to Healthcare sector averages

Net Margin
TSHA 0.0%
vs
Sector Avg 12.0%
TSHA Sector
ROE
TSHA -20.0%
vs
Sector Avg 15.0%
TSHA Sector
Current Ratio
TSHA 14.0x
vs
Sector Avg 2.0x
TSHA Sector
Debt/Equity
TSHA 0.2x
vs
Sector Avg 0.6x
TSHA Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Taysha Gene Therapies, Inc. Stock Overvalued? TSHA Valuation Analysis 2026

Based on fundamental analysis, Taysha Gene Therapies, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-20.0%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.23x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Taysha Gene Therapies, Inc. Balance Sheet: TSHA Debt, Cash & Liquidity

Current Ratio
14.04x
Quick Ratio
14.04x
Debt/Equity
0.23x
Debt/Assets
29.4%
Interest Coverage
-776.54x
Long-term Debt
$49.0M

TSHA Revenue & Earnings Growth: 5-Year Financial Trend

TSHA 5-year financial data: Year 2022: Revenue $2.5M, Net Income -$174.5M, EPS $-4.64. Year 2023: Revenue $15.5M, Net Income -$166.0M, EPS $-3.78. Year 2024: Revenue $15.5M, Net Income -$111.6M, EPS $-0.96. Year 2025: Revenue $9.8M, Net Income -$89.3M, EPS $-0.36.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Taysha Gene Therapies, Inc.'s revenue has grown significantly by 291% over the 5-year period, indicating strong business expansion. The most recent EPS of $-0.36 indicates the company is currently unprofitable.

TSHA Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

TSHA Quarterly Earnings & Performance

Quarterly financial performance data for Taysha Gene Therapies, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 N/A -$21.5M $-0.08
Q3 2025 N/A -$25.5M $-0.09
Q2 2025 $1.1M -$20.9M $-0.09
Q1 2025 $2.3M -$21.5M $-0.08
Q3 2024 $1.8M -$25.5M $-0.10
Q2 2024 $1.1M -$20.9M $-0.09
Q1 2024 $3.4M -$17.6M $-0.10
Q3 2023 $4.7M -$26.5M $-0.65

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Taysha Gene Therapies, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$40.9M
Cash generated from operations
Capital Expenditures
$24.0K
Investment in assets
Dividends
None
No dividend program

TSHA SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Taysha Gene Therapies, Inc. (CIK: 0001806310)

📋 Recent SEC Filings

Date Form Document Action
Jun 2, 2026 4 xslF345X06/form4-06022026_040616.xml View →
Jun 2, 2026 4 xslF345X06/form4-06022026_040614.xml View →
Jun 2, 2026 4 xslF345X06/form4-06022026_040612.xml View →
Jun 2, 2026 4 xslF345X06/form4-06022026_040610.xml View →
Jun 2, 2026 8-K d159199d8k.htm View →

Frequently Asked Questions about TSHA

What is the AI rating for TSHA?

Taysha Gene Therapies, Inc. (TSHA) has an AI grade of B with 65% confidence, based on fundamental analysis of SEC EDGAR filings.

What are TSHA's key strengths?

Claude: Exceptional cash position of $276.6M with minimal capex needs, providing substantial operational runway. Strong balance sheet with 14.04x current ratio and conservative 0.23x debt-to-equity leverage.

What are the risks of investing in TSHA?

Claude: Zero revenue generation with no clear commercialization timeline or product approval visibility. Annual operating burn of $40.9M requires successful R&D execution to justify cash deployment.

What is TSHA's revenue and growth?

Taysha Gene Therapies, Inc. reported revenue of $0.0.

Does TSHA pay dividends?

Taysha Gene Therapies, Inc. does not currently pay dividends.

Where can I find TSHA SEC filings?

Official SEC filings for Taysha Gene Therapies, Inc. (CIK: 0001806310) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is TSHA's EPS?

Taysha Gene Therapies, Inc. has a diluted EPS of $-0.12.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is TSHA's fundamental grade?

Based on our AI fundamental analysis in June 2026, Taysha Gene Therapies, Inc. has a B grade with 65% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is TSHA stock overvalued or undervalued?

Valuation metrics for TSHA: ROE of -20.0% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is TSHA's AI grade for 2026?

Our dual AI analysis gives Taysha Gene Therapies, Inc. a combined B grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is TSHA's free cash flow?

Taysha Gene Therapies, Inc.'s operating cash flow is $-40.9M, with capital expenditures of $24.0K.

How does TSHA compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -20.0% (avg: 15%), current ratio 14.04 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 8, 2026 | Data as of: 2026-03-31 | Powered by Claude AI