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VYNE Therapeutics Inc. (VYNE) Fundamental Analysis & AI Grade 2026

VYNE Nasdaq Pharmaceutical Preparations DE CIK: 0001566044
Updated This Month • Analysis: May 16, 2026 • SEC Data: 2026-03-31
Combined AI Grade
C
75% Confidence
N/A
C
75% Conf
Pending
Analysis scheduled

📊 VYNE Key Takeaways

Revenue: $86.0K
Net Margin: -4,168.6%
Free Cash Flow: $-4.1M
Current Ratio: 20.86x
Debt/Equity: 0.00x
EPS: $-0.08
AI Grade: C with 75% confidence
VYNE Therapeutics Inc. (VYNE) receives a C fundamental grade with 75% confidence from our AI analysis based on SEC 10-K filings. With revenue of $86.0K, net profit margin of -4,168.6%, and return on equity (ROE) of -14.6%, VYNE Therapeutics Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete VYNE stock analysis for 2026.

Is VYNE Therapeutics Inc. (VYNE) a Good Investment?

Claude

VYNE demonstrates adequate financial cushion with $24.6M cash and zero debt, but faces critical commercialization failure with near-zero revenue ($86K) despite significant operating losses (-$3.8M) and negative cash flow (-$4.1M). For a pharmaceutical company, minimal revenue suggests failed product launches or stalled pipeline with approximately six years of runway at current burn rate before capital depletion.

VYNE Therapeutics Inc. Key Strengths (VYNE)

Claude
  • + Strong cash position of $24.6M with no long-term debt provides financial runway
  • + Excellent liquidity metrics (20.86x current ratio) enable debt service and operations
  • + Positive stockholders' equity of $24.6M maintains solvency and balance sheet integrity

VYNE Stock Risks: VYNE Therapeutics Inc. Investment Risks

Claude
  • ! Near-zero revenue ($86K) indicates failed commercialization or stalled product adoption for a pharmaceutical company
  • ! Significant operating losses (-$3.8M) and negative free cash flow (-$4.1M) destroy shareholder value with ROE of -14.6% and ROA of -13.9%
  • ! Finite cash runway of approximately six years at current burn rate without revenue growth creates existential timeline pressure

Key Metrics to Watch

Claude
  • * Revenue growth trajectory and product commercialization progress
  • * Operating cash flow trend to assess if burn rate is accelerating or stabilizing
  • * Cash balance depletion rate and remaining runway before capital exhaustion

VYNE Therapeutics Inc. (VYNE) Financial Metrics & Key Ratios

Revenue
$86.0K
Net Income
$-3.6M
EPS (Diluted)
$-0.08
Free Cash Flow
$-4.1M
Total Assets
$25.9M
Cash Position
$24.6M

💡 AI Analyst Insight

Strong liquidity with a 20.86x current ratio provides a solid financial cushion.

VYNE Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -4,437.2%
Net Margin -4,168.6%
ROE -14.6%
ROA -13.9%
FCF Margin -4,745.3%

VYNE vs Healthcare Sector: How VYNE Therapeutics Inc. Compares

How VYNE Therapeutics Inc. compares to Healthcare sector averages

Net Margin
VYNE -4,168.6%
vs
Sector Avg 12.0%
VYNE Sector
ROE
VYNE -14.6%
vs
Sector Avg 15.0%
VYNE Sector
Current Ratio
VYNE 20.9x
vs
Sector Avg 2.0x
VYNE Sector
Debt/Equity
VYNE 0.0x
vs
Sector Avg 0.6x
VYNE Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is VYNE Therapeutics Inc. Stock Overvalued? VYNE Valuation Analysis 2026

Based on fundamental analysis, VYNE Therapeutics Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-14.6%
Sector avg: 15%
Net Profit Margin
-4,168.6%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

VYNE Therapeutics Inc. Balance Sheet: VYNE Debt, Cash & Liquidity

Current Ratio
20.86x
Quick Ratio
20.86x
Debt/Equity
0.00x
Debt/Assets
4.8%
Interest Coverage
N/A
Long-term Debt
$0.0

VYNE Revenue & Earnings Growth: 5-Year Financial Trend

VYNE 5-year financial data: Year 2021: Revenue $21.0M, Net Income -$255.6M, EPS $7.88. Year 2022: Revenue $931.0K, Net Income -$73.3M, EPS $-25.64. Year 2023: Revenue $477.0K, Net Income -$23.2M, EPS $-7.28. Year 2024: Revenue $501.0K, Net Income -$28.5M, EPS $-2.78. Year 2025: Revenue $570.0K, Net Income -$39.8M, EPS $-0.93.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: VYNE Therapeutics Inc.'s revenue has declined by 97% over the 5-year period, indicating business contraction. The most recent EPS of $-0.93 indicates the company is currently unprofitable.

VYNE Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-4,745.3%
Free cash flow / Revenue

VYNE Quarterly Earnings & Performance

Quarterly financial performance data for VYNE Therapeutics Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $86.0K -$3.6M $-0.08
Q2 2025 $69.0K -$5.8M $-0.13
Q1 2025 $98.0K -$6.2M $-0.15
Q3 2024 $114.0K -$6.6M $-0.29
Q2 2024 $135.0K -$9.4M $-0.22
Q1 2024 $98.0K -$5.6M $-0.15
Q3 2023 $114.0K -$6.6M $-2.01
Q2 2023 $126.0K -$3.8M $-1.21

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

VYNE Therapeutics Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$4.1M
Cash generated from operations
Dividends Paid
$16.5M
Returned to shareholders

VYNE SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for VYNE Therapeutics Inc. (CIK: 0001566044)

📋 Recent SEC Filings

Date Form Document Action
Jun 2, 2026 4 xslF345X06/form4-06022026_050601.xml View →
May 21, 2026 8-K tm2615387d1_8k.htm View →
May 15, 2026 10-Q vyne-20260331.htm View →
Apr 2, 2026 4 xslF345X06/form4-04022026_040408.xml View →
Apr 2, 2026 4 xslF345X06/form4-04022026_040407.xml View →

Frequently Asked Questions about VYNE

What is the AI rating for VYNE?

VYNE Therapeutics Inc. (VYNE) has an AI grade of C with 75% confidence, based on fundamental analysis of SEC EDGAR filings.

What are VYNE's key strengths?

Claude: Strong cash position of $24.6M with no long-term debt provides financial runway. Excellent liquidity metrics (20.86x current ratio) enable debt service and operations.

What are the risks of investing in VYNE?

Claude: Near-zero revenue ($86K) indicates failed commercialization or stalled product adoption for a pharmaceutical company. Significant operating losses (-$3.8M) and negative free cash flow (-$4.1M) destroy shareholder value with ROE of -14.6% and ROA of -13.9%.

What is VYNE's revenue and growth?

VYNE Therapeutics Inc. reported revenue of $86.0K.

Does VYNE pay dividends?

VYNE Therapeutics Inc. pays dividends, with $16.5M distributed to shareholders in the trailing twelve months.

Where can I find VYNE SEC filings?

Official SEC filings for VYNE Therapeutics Inc. (CIK: 0001566044) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is VYNE's EPS?

VYNE Therapeutics Inc. has a diluted EPS of $-0.08.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is VYNE's fundamental grade?

Based on our AI fundamental analysis in June 2026, VYNE Therapeutics Inc. has a C grade with 75% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is VYNE stock overvalued or undervalued?

Valuation metrics for VYNE: ROE of -14.6% (sector avg: 15%), net margin of -4,168.6% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is VYNE's AI grade for 2026?

Our dual AI analysis gives VYNE Therapeutics Inc. a combined C grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is VYNE's free cash flow?

VYNE Therapeutics Inc.'s operating cash flow is $-4.1M, with capital expenditures of $0.0. FCF margin is -4,745.3%.

How does VYNE compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -4,168.6% (avg: 12%), ROE -14.6% (avg: 15%), current ratio 20.86 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 16, 2026 | Data as of: 2026-03-31 | Powered by Claude AI